I assume you're not taking the 77 because you have done it many times before.

I went from Daytona to Philly in one day.
Just over 1000 miles.
Been up and down that run more than 10 times.

Florida is easy.
Georgia sets speed traps at mile marker 8.
Boring as all hell until you get to Richmond. Then I recommend looping the 295 around. Downtown Richmond traffic/construction can stop traffic at strange hours.
Starting at Frederick, MD, the DC traffic starts making a mess of things.
Do NOT get near DC between 06 and 1000, and 1400-1900.
Then the 270-70-76 to get to Ohio?

Speeds: Traffic flows 75-80 all the way, except Georgia and speed zones in SC. VA troopers have an attitude towards bikes.
If there's an accident, traffic backs up for tens of miles. Shoulder to nearest exit, food time.

It can also have it's own weather system in certain parts.

Cheers,
Steve