Recommend that you research it to see where you might want to angle down. I'd probably do it in Missouri. I've ridden over to Arkansas several times and we always take US-50, -160, -400, etc across Kansas. Have also stayed south of I-70 in Missouri. LOTS of heavy truck traffic on I-70 in Missouri and they love to try to pass each other backing up traffic. I just prefer to find routing to avoid heavy truck traffic when I am on the bike.
2016 F6B Deluxe
Jupiter Orange Metallic