With a conventional radial tire (non-run flat) and Ride-On Tire Balancer/Sealant there is no difference in thread/tread puncture protection IMHO. The ability to continue to use the tire after a puncture is the same The added benefit of a stiff sidewall and more MC Tire like ride achieved with lower air pressure (sweet spot) of course, is not the same as a softer 1 ply side-walled conventional tire. Therein lies the real difference.
I'm anxious to see this tire after 25/30K miles of wear and specifically what the tire edges look like! The wear characteristics should be interesting