These bikes can easily last for hundreds of thousands of miles. I still own a 1999 Valkyrie Interstate with 102,000 miles. The only thing I've ever fixed was a broken clutch cable. I also have a 1998 Valkyrie Tourer with 176,000 miles. It has needed a rear wheel bearing at 50K and clutch damper plate at 140K, which were common issues but easy fixes. But mine are low mileage examples. I met a rider at a VRCC rally who had 690,000 miles on his Valkyrie as of a few months ago.

Valkyries use the GL1500 engine that Honda introduced in the 1980s. I'd think our newer GL1800s could last even longer.