If you want something to carry into the hotel (which I prefer) this is my favorite bag of all time from Saddlemen:

http://www.saddlemen.com/products/k2...y-bar-bag.html

I've used this for several years on my Heritage Softail and Road King. Durable, lots of exterior pockets, holds a ton, stays dry in light to moderate rain, comes with a rain cover for heavy rain. It also has the best backrest attachment system I have had in this type of bag. The F6B back rest is very wide but this bag fits securely on mine.

You can also sit this bag 180 degrees on the stock passenger seat while attached to the passenger backrest. I tried this, plenty of room on the stock rear seat and it does not get into the riders back. If it were packed full just lean back a bit for a backrest.