Every year I go up but just for the day. Always depends on work but usually Wed or Thurs.
A few of us will head out in the AM and take the scenic way up either RT7 or RT22 to Cambridge and then across to 87 for the last 15miles into Lake George, with a couple stops along the way up that takes just under 4 hrs to get there. We take a quick walk around the Vendors (one of us always needs some little thing) and walk up to Main St for Lunch and head back. That is all I ever have time for but it takes pretty much all day.