This route has taken me from the Lodge at Tellico to Suches, up Wolf Pen Gap (180), down Blood Mountain (19), continue on 129 to 75A, up to the Richard B Russel (348) - I KNOW Teach took you there.
Then up to 180 again, and then down the Unicoi Turnpike to Helen for lunch.

Also gives you the option of running the 75A south, to 129 and do Blood Mountain south to north and the RBR north to south after lunch!
Enjoy.

https://goo.gl/maps/cGpDA8kHiR22

Cheers,
Steve