If you are looking to make good time a direct run from the Pa/NY border would be RT15 south. That will run you along the Susquehanna River. It will be scenic at times but a nascar race with cagers in some areas. The mountains of central PA offer some fantastic roads to ride on a bike. Most roads you see on a PA map that are cutting through any State gameland or State forest are ones you want to run if you can. Some good ones I would suggest on the west side of RT15 would be RT144, Rt44, and Rt120. On the east side of RT15 I would suggest RT14,154,87,442, and 487. If you have the time and want to ride one of the best roads in PA you want to run RT339 between Mahoney City and Bloomsburg. This is a hidden gem of a road and it takes you right across a mountain top loaded with wind turbines just outside of Mahoney City. It's recently been re-paved with lots of twist and turns through the country!
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