I'm 5'10, 250# and a 30" inseam. The OEM seat would start hurting at about 30-45 minutes of riding, and I couldn't flat foot the bike.
I sent my seat to Mean City Cycles for work. They shaved the sides making it narrower, lowered the seat by about 1.5", installed memory foam in the seat and backrest, and added seat heaters.
Rode for almost 4 hours straight yesterday and no problems whatsoever. Well cagers are still a problem, but that has nothing to do with the seat. And now I can flat foot the bike in sneakers!