For large hands? I like my Glock 30SF. The staggered magazine fattens the grip nicely and makes the reach for the trigger more natural and not an exercise in micro-ergonomics.
It's very comfortable and conceals fairly well.
Oh, and it's pretty dang accurate to 15 yards.
At 25 yards it seems to get a bit more random (paper plate size groupings) but how often is that going to be a requirement in self-defense?
Cheers,
Steve