Short answer: no.
Slightly longer answer:
All of our fuels in Philly have the "up to 10% ethanol" label on them and I am not ready to do what my neighbor MadMax is doing and removing that from the mix. Yet.
Just like any entity, I think varying the diet is a good thing - make the system work under slightly different parameters.
Performance difference? Nope. She still goes like a scalded cat no matter what grade I use.
She does get some Sea Foam every 4th tankful just to keep everything clean and happy.
If I know I'll be on a highway at constant higher RPMs, I'll use the highest grade octane I can for a tankful - again to keep the system clean and running optimally under different operating parameters.
Fuel efficiency - for me - is more a function of "am I commuting?" (which is 12 miles of 20, 25 & 35 mph roads with 47 stoplights) or "am I not commuting?"
Hope this helps.
Steve