From Harrisburg it should only take you 11 hrs. to Maggie Valley. Remember too, your riding your new bike, is pushing it during the break in period a good idea? Take your time and vary the speeds. If you got the time stop in Maggie Valley and ride the Dragon or visit the bike museum.
I wouldn't worry too much about the weather difference between 95 and 81 as long as there's no front coming through. Your south of the real cold weather.